Neurogénesis hipocampal adulta y envejecimiento cognitivo

Román Darío Moreno Fernández; Carmen Pedraza; Milagros Gallo

doi:10.24310/espsiescpsi.v6i3.13285

Autores/as

Román Darío Moreno Fernández Departmento de Psicobiología. Instituto de Neurociencias. Centro de Investigaciones Biomédicas (CIBM). Universidad de Granada; departamento de Psicobiología y Metodología en CC. Universidad de Málaga. Instituto de Investigaciones Biomédicas de Málaga (IBIMA) España
Carmen Pedraza Departamento de Psicobiología y Metodología en CC. Universidad de Málaga. Instituto de Investigaciones Biomédicas de Málaga (IBIMA) España
Milagros Gallo Departmento de Psicobiología. Instituto de Neurociencias. Centro de Investigaciones Biomédicas (CIBM). Universidad de Granada España

DOI:

https://doi.org/10.24310/espsiescpsi.v6i3.13285

Palabras clave:

Neurogénesis hipocampal adulta, Envejecimiento, Deterioro Cognitivo, Memoria Espacial

Resumen

El envejecimiento es un proceso normal en el desarrollo del organismo asociado a una serie de cambios neurobiológicos que producen alteraciones cognitivas con funciones preservadas, deterioradas y facilitadas. Se revisa la evidencia obtenida con animales y humanos a fin de explorar un posible papel de la plasticidad hipocampal en los cambios cognitivos asociados con la edad, con especial atención a la neurogénesis hipocampal adulta. Los resultados obtenidos empleando las estrategias de lesión, estimulación, así como datos correlacionales apoyan un papel, ya sea directo, ya sea modulador de las nuevas neuronas en la ejecución cognitiva a edades avanzadas. Avances en la investigación de esta relación pueden favorecer el desarrollo de nuevos tratamientos y la mejora de la calidad de vida de la población de más edad.

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