Repeated DNA sequences: Who said junk DNA?

Authors

  • Enrique Viguera Martínez Spain

Keywords:

sequences, DNA, repeated, dynamic mutations

Abstract

Repeated DNA sequences are very abundant in both eukaryotic and prokaryotic genomes. These sequences are hot spots of mutation and genomic instability and are characterized by reversible changes in the length of the repeated sequence, so that these changes are known as dynamic mutations. The discovery that the instability of repeats affects gene regulation, transcription or protein function as a molecular switch, gives them a key role in the evolution of organisms.

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References

(Lorente, JA. Genética forense: de la escena del crimen al laboratorio. 2010. En Encuentros con la Ciencia II: del macrocosmos al microcosmos. Capítulo 10. pp 115-126. Viguera E, Grande, A. y Lo- zano, J. (coordinadores). Servicio de Publicaciones de la Universidad de Málaga. www.encuentrosconlaciencia.es

Moxon ER, Wills C. Microsatélites de ADN. Investigación y Ciencia. Temas 38: 14-19

Ellegren, H. Microsatellites: simple sequences with complex evolution. Nat Rev. Genet. 2004; 5: 435- 445 (4) Perucho M. Cáncer del fenotipo mutador de microsatélites. Investigación y Ciencia. 1998; 261: 46-55

!"# Viguera E, Canceill D, Ehrlich SD. Replication slippage involves DNA polymerase pausing and disso- ciation. EMBO Journal (2001). 20: 2587 –2595

ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome.

Nature. 2012; 489: 57-74

Maher, B. Fighting about ENCODE and junk. http://blogs.nature.com/news/2012/09/fig hting-about-encode-and-junk.html

Published

2013-03-20

How to Cite

Viguera Martínez, E. (2013). Repeated DNA sequences: Who said junk DNA?. Encuentros En La Biología, 6(142), 5–7. Retrieved from https://revistas.uma.es/index.php/enbio/article/view/18378