Cancer, genes and genomes

Authors

  • Carlos López Otín Spain

Keywords:

cancer, genes, genomes

Abstract

Cancer is a disease whose ability to make us feel vulnerable seems to increase every day. The World Health Organization’s forecasts for the year 2020 speak of 16 million new diagnoses and 10 million fatal victims. However, despite these overwhelming numbers that almost liken cancer to a modern epidemic, we are not facing a recent pathology, just remember its origin to convince ourselves of this. Indeed, after the formation of the first cells more than three billion years ago, life on our planet took place in an exclusively unicellular environment. Millennium after millennium, unicellular life dominated the Earth until about 800 million years ago, one of these primitive cells successfully shared its life with others like it, initiating the process that led them to build multicellular organisms. It was also at that moment when the first pathways that would later lead to cancer began to take shape

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References

Kulis M et al “Epigenetic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia” Nature Genetics 44: 1236-1242 (2012)

Puente XS and López-Otín C “The evolutionary biography of chronic lymphocytic leukemia” Nature Genetics 44: 1236-1242 (2012)

Puente XS et al "Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukemia” Nature 475: 101-105 (2011)

Quesada V et al “Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia” Nature Genetics 44: 47-52 (2012)

Ramsay AJ, Quesada V, Foronda M, Conde L, Martínez-Trillos A, Villamor D, Rodríguez D, Kwarciak A, Garabaya C, Gallardo M, López-Guerra M, López-Guillermo A, Puente XS, Blasco MA, Campo E, and López-Otín C. “POT1 mu- tations cause telomere dysfunction in chronic lymphocytic leukemia” Nature Genetics 45: 526-530 (2013)

Published

2014-09-20

How to Cite

López Otín, C. (2014). Cancer, genes and genomes. Encuentros En La Biología, 7(150), 127–130. Retrieved from https://revistas.uma.es/index.php/enbio/article/view/18143