Is cellular rejuvenation possible?

Authors

  • Ignacio Ramírez Pardo Spain

Keywords:

rejuvenation, anti-aging, iPSCs, CRISPR-CAS9, muscular dystrophy

Abstract

Aging is a gradual and intrinsic cellular process influenced by lifestyle that alters cellular homeostasis. iPSCs generation allowed cellular reprogramming and even rejuvenate cells. Moreover, genome editing tools such as CRISPR/Cas9 and culture medium changes may allow iPSCss production of aged individuals. This article shows how the combination of these revolutionary technologies can be used to treat aging-associated diseases

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

References

Williams G. George Williams antagonistic pleiotropy theory of aging. Evolution 11(4): 398-411, 1957.

Kirkwood T. Evolution of ageing. Mechanisms of ageing and development 123(7) 37-745, 2002.

López-Otín C y otros. The hallmarks of aging. Cell 153(6): 1194-1207, 2013.

Zhang R y otros. The Four Layers of Aging. Cell Systems 1(3): 180–186 http://doi.org/10.1016/j.cels.2015.09.002.

Geiger H y Jasper H. Stem Cell Aging: Mechanisms, Consequences, Rejuvenation. Vienna: Springer Vienna, 2015.

Garatachea N y otros. Exercise Attenuates the Major Hallmarks of Aging. Rejuvenation Research, 18(1): 57–89, 2015. http://doi.org/10.1089/rej.2014.1623.

Lee J y otros. Beta-Lapachone, a Modulator of NAD Metabolism , Prevents Health Declines in Aged Mice. PLoS ONE, 7(10), 2012 http://doi.org/10.1371/journal.pone.0047122.

Takahashi, K. y Yamanaka, S. (2006). Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors. Cell, 126(4), 663–676. http://doi.org/10.1016/j.cell.2006.07.024

Takahashi K y otros. Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors. Cell, 131 (5):861–872, 2007.

Soria-Valles C y López-Otín C. iPSCs: On the Road to Reprogramming Aging. Trends in Molecular Medicine, vol. xx: 1–12, 2016.

Oh J y otros. Stem cell aging: mechanisms, regulators and therapeutic opportunities. Nature Medicine, 20(8):870–880, 2014. http://doi.org/10.1038/nm.365.

Rando S y otros. Aging, rejuvenation, and epigenetic reprogramming: Resetting the aging clock. Cell, 148(1–2):46–57, 2012. http://doi.org/10.1016/j.cell.2012.01.003.

Pareja-Galeano H y otros. IPSCs-based anti-aging therapies: Recent discoveries and future challenges. Ageing Research Review, 27:37–41, 2016.

Nguyen A y otros. The diverse functions of Dot1 and H3K79 methylation. Genes and development; 3:1345–1358.

http://doi.org/10.1101/gad.2057811.ute

Rony I y otros. Inducing pluripotency in vitro: Recent advances and highlights in induced pluripotent stem cells generation and pluripotency reprogramming. Cell Proliferation, 48(2):140–156, 2015. http://doi.org/10.1111/cpr.12162.

Mojica FJM y otros. Short motif sequences determine the targets of the prokaryotic CRISPR defence system. Microbiology, 155(3): 733–740, 2009.

Merkle FT y otros. Efficient CRISPR-Cas9-Mediated Generation of Knockin Human Pluripotent Stem Cells Lacking Undesired Mutations at the Targeted Locus. Cell Reports, 11(6):875–883, 2015.

Guiraud, S y otros. Advances in genetic therapeutic strategies for Duchenne muscular dystrophy. Experimental Physiology 12:1458 1467,2015. http://doi.org/10.1113/EP085308

Published

2016-12-14

How to Cite

Ramírez Pardo, I. (2016). Is cellular rejuvenation possible?. Encuentros En La Biología, 9(160), 175–179. Retrieved from https://revistas.uma.es/index.php/enbio/article/view/17934

Issue

Section

Artículos