cellular reprogramming

Authors

  • Manuel Serrano Spain

Keywords:

reprogramming, cellular, manipulate

Abstract

Scientists are starting to understand the plasticity of cellular identity and to manipulate it in a controlled manner. This emerging field of research may open new strategies in regenerative medicine. Here, I discuss some of the pending issues, including the possible con- nection between cellular plasticity and cancer.

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References

Kurian, L., Sancho-Martinez, I., Nivet, E., Aguirre, A., Moon, K., Pendaries, C., Volle-Challier, C., Bono, F., Herbert, J.M., Pulecio, J., et al. (2013). Conversion of human fibroblasts to angioblast- like progenitor cells. Nat Methods 10, 77-83.

Ladewig, J., Koch, P., and Brustle, O. (2013). Leveling Waddington: the emergence of direct pro- gramming and the loss of cell fate hierarchies. Nat Rev Mol Cell Biol 14, 225-236.

Li, H., Collado, M., Villasante, A., Strati, K., Ortega, S., Canamero, M., Blasco, M.A., and Serrano, M. (2009). The Ink4/Arf locus is a barrier for iPS cell reprogramming. Nature 460, 1136-1139.

Li, W., Jiang, K., and Ding, S. (2012). Concise review: A chemical approach to control cell fate and function. Stem Cells 30, 61-68.

Marion, R.M., Strati, K., Li, H., Murga, M., Blanco, R., Ortega, S., Fernandez-Capetillo, O., Ser- rano, M., and Blasco, M.A. (2009). A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity. Nature 460, 1149-1153.

Polo, J.M., Anderssen, E., Walsh, R.M., Schwarz, B.A., Nefzger, C.M., Lim, S.M., Borkent, M., Apos- tolou, E., Alaei, S., Cloutier, J., et al. (2012). A molecular roadmap of reprogramming somatic cells into iPS cells. Cell 151, 1617-1632.

Suva, M.L., Riggi, N., and Bernstein, B.E. (2013). Epigenetic reprogramming in cancer. Science 339, 1567-1570.

Takahashi, K., and Yamanaka, S. (2006). Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663-676.

Published

2013-07-20

How to Cite

Serrano, M. (2013). cellular reprogramming . Encuentros En La Biología, 6(143), 29–32. Retrieved from https://revistas.uma.es/index.php/enbio/article/view/18368