Frederick Sanger: the man who turned genes into sequences

Authors

  • Miguel García Sancho United Kingdom

Keywords:

Federeick Sanger, RNA, DNA

Abstract

Frederick Sanger, the inventor of the techniques which enable to transform biological molecules (proteins, RNA and DNA) into sequences of information bearing their basic chemical structure, died last 19th November at the age of 95. Sanger left this world as he lived in it: silently and avoiding the public eye. However, his contribu- tions are still essential in the age of genomic research and personalized medicine.

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References

Sobre Hopkins, Cambridge y la historia de la bioquímica ver a) http://www.bioc.cam.ac.uk/about/his- tory; b) Kamminga H. y Weatheral M.W. (1996) “The making of a biochemist. I: Frederick Gowland Hopkins' construction of dynamic biochemistry”, Medical History, 40(3): 269-92; c) Martínez del Pozo

A. (2009) El nacimiento de la química de proteínas: de la ovalbúmina a la estructura de la hemoglo- bina, 1800-1960 (Editorial Nívola).

Sobre el descubrimiento de la doble hélice de ADN y el Laboratorio de Biología Molecular de Cam- bridge ver a) http://www.nobelprize.org/educational/medicine/d na_double_helix/readmore.html y http://www2.mrc-lmb.cam.ac.uk/about- lmb/history-of-the-lmb/; b) Olby R. (1991) El camino hacia la doble hélice (Alianza Editorial); c) Valpuesta J.M. (2008) A la búsqueda del secreto de la vida: una breve historia de la biología molecular (Editorial Hélice).

Sobre las técnicas de secuenciación de Sanger y su automatización (incluyendo vídeos y gráficos explicativos) ver a) http://www.institutoroche.es/Biotecnologia_editori al/V44.html; b) García-Sancho

M. (2010) “A new insight into Sanger’s development of sequencing: from proteins to DNA, 1943-1977”, Journal of the History of Biology, 43(2): 265-323.

Sobre el Instituto Sanger y el Proyecto Genoma Humano ver a) http://www.sanger.ac.uk/about/histo- ry/; b) Cook- Deegan R. (1994) The Gene Wars: Science, Politics and the Human Genome (Norton).

Ver a) Sanger F. (1988) “Sequences, sequences and sequences”, Annual Review of Biochemistry, 57: 1-29; b) García-Sancho M. (2012) Biology, Computing and the History of Molecular Sequencing: From Proteins to DNA, 1945-2000 (Palgrave Macmillan). Sobre el New Generation Sequencing ver http://core- genomics.blogspot.co.uk/2013/11/sanger-seq-is- dead-if-you-only-read- one.htmlFlavonoid- Wikipedia (https://en.wikipedia.org/wiki/Flavonoid)

Published

2014-07-20

How to Cite

García Sancho , M. (2014). Frederick Sanger: the man who turned genes into sequences. Encuentros En La Biología, 7(149), 101. Retrieved from https://revistas.uma.es/index.php/enbio/article/view/18181

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Artículos