New layer of information: epitranscriptomics

Authors

  • Rafael A. Cañas Spain

DOI:

https://doi.org/10.24310/enbio.v9i166.17491

Keywords:

epitranscriptomics, modified nucleosides, translation regulation

Abstract

The nucleosides of nucleic acids (DNA and RNA) undergo chemical modifications, mainly in their nitrogenous bases, which constitute a new layer of information. The set of modifications suffered by RNA is known as epitranscriptome. In this article, we review the physiological importance of the epitranscriptome, mainly in the regulation of translation.

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References

Grosjean H. Modification and editing of RNA: historical overview and important facts to remember. In: Grosjean H. (eds) Fine-Tuning of RNA Functions by Modification and Editing. Topics in Current Genetics, vol 12. Springer, Berlin, Heidelberg, 2005.
Sood AJ y otros. DNAmod: the DNA modification database.bioRxiv. 071712, 2018.
Boccaletto P y otros. MODOMICS: a database of RNA modification pathways. 2017 update. Nucleic Acids Res. 46: D303–D307, 2018.
Nicoglou A y Merlin F. Epigenetics: A way to bridge the gap between biological fields. Stud. Hist. Philos. Biol. Biomed. Sci. 66: 73-82, 2017.
Luo C y otros. Dynamic DNA methylation: In the right place at the right time. Science 361: 1336-1340, 2018.
Sloan K y otros. Tuning the ribosome: The influence of rRNA modification on eukaryotic ribosome biogenesis and function. RNA Biol. 14: 1138-1152, 2017.
7
Soko?owski M y otros. Cooperativity between different tRNA modifications and their modification pathways. Biochim. Biophys. Acta Gene Regul. Mech. 1861: 409-418, 2018.
Dubin DT y Taylor RH. The methylation state of poly A-containing messenger RNA from cultured hamster cells. Nucleic Acids Res. 2: 1653-1668, 1975.
Perry RP y Kelley DE. Methylated constituents of heteroge- neous nuclear RNA: Presence in blocked 50 terminal structures. Cell 6: 13-19, 1975.
Saletore Y y otros. The birth of the Epitranscriptome: deciphering the function of RNA modifications. Genome Biol. 13: 175, 2012.
Peer E y otros. The Epitranscriptome in Translation Regula- tion. Cold Spring Harb. Perspect. Biol. pii: a032623, 2018.
Karijolich J y Yu YT. Converting nonsense codons into sense codons by targeted pseudouridylation. Nature 474: 395-398, 2011.
Yang X y otros. 5-methylcytosine promotes mRNA ex-port—NSUN2 as the methyltransferase and ALYREF as an m5C reader. Cell Res. 27: 606-625, 2017.
Vandivier LE y Gregory BD. New insights into the plant epitranscriptome. J. Exp. Bot. 69: 4659-4665, 2018.
Tang C y otros. ALKBH5-dependent m6A demethylation controls splicing and stability of long 30-UTR mRNAs in male germ cells. Proc. Natl. Acad. Sci. 115: E325-E333, 2017.

Published

2019-03-20

How to Cite

Cañas , R. A. . (2019). New layer of information: epitranscriptomics. Encuentros En La Biología, 9(166), 28–31. https://doi.org/10.24310/enbio.v9i166.17491