Las hojas de olivo, fuente de compuestos bioactivos que podrían ayudarnos a combatir los coronavirus además de al VIH

Autores/as

  • Carolina Valle Piqueras España

DOI:

https://doi.org/10.24310/enbio.v13i174.17278

Palabras clave:

Hojas de olivo, coronavirus, VIH

Resumen

En este estudio se presentan tres razones por las cuales se propone que las hojas de olivo quizás   nos podrían ayudar a hacer frente a las infecciones por VIH y por coronavirus tales como SARS-CoV y SARS-CoV-2 (COVID-19)

Descargas

Los datos de descargas todavía no están disponibles.

Métricas

Cargando métricas ...

Citas

Bertelli M y otros. Hydroxytyrosol: A natural compound with promising pharmacological activities. J Biotechnol. 10;309:29- 33, 2020.
Syed Haris Omar. Oleuropein in olive and its pharmacological effects. Sci Pharm 78(2):133-54, 2010.
Himour S, Yahia A y Belattar H. Oleuropein and Antibacterial Activities of Olea europaea L. Leaf Extract. European Scientific Journal vol.13, No.6, 2017.
Xu Y y otros. Crystal structure of severe acute respiratory syndrome coronavirus spike protein fusion core. J Biol Chem. 19;279(47):49414-9, 2004.
Lee-Huang S y otros. Discovery of Small-Molecule HIV-1 Fu- sion and Integrase Inhibitors Oleuropein and Hydroxytyrosol: I. Fusion Inhibition. Biochem Biophys Res Commun 23; 354(4): 872–878, 2007.
Lee-Huang S y otros. Anti-HIV activity of olive leaf extract (OLE) and modulation of host cell gene expression by HIV-1 infection and OLE treatment. Biochem Biophys Res Commun 8;307(4):1029-37, 2003.
[7] Bao J, Zhang DW, Zhang JZ, Huang PL, Huang PL, Lee-Huang
S. Computational study of bindings of olive leaf extract (OLE) to HIV-1 fusion protein gp41. FEBS Lett 12;581(14):2737-42, 2007.
[8] Chunyun Sun y otros. SARS-CoV-2 and SARS-CoV Spike-RBD Structure and Receptor Binding Comparison and Potential Im- plications on Neutralizing Antibody and Vaccine Development.
BioRxiv, 2020. DOI: 10.1101/2020.02.16.951723
[9] Susalit E y otros. Olive (Olea europaea) leaf extract effective in patients with stage-1 hypertension: comparison with Captopril. Phytomedicine 15;18(4):251-8, 2011.
[10] Alcaide-Hidalgo JM, Romero M, Duarte J, López-Huertas E. Antihypertensive Effects of Virgin Olive Oil (Unfiltered) Low Molecular Weight Peptides with ACE Inhibitory Activity in Spontaneously Hypertensive Rats. Nutrients 20;12(1), pii: E271, 2020.
Siddell S, Wege H, Ter Meulen V. The biology of coronaviruses. J Gen Virol 64 (Pt 4):761-76, 1983.
Cavanagh D. Coronavirus IBV: structural characterization of the spike protein. J Gen Virol 64 (Pt 12):2577-83, 1983.
Tsang KW, Mok TY, Wong PC, Ooi GC. Severe acute respira- tory syndrome (SARS) in Hong Kong. Respirology 8(3):259-65, 2003.
Longxian Lv, Gaolei Li, Jinhui Chen, Xinle Liang, Yudong Li. Cao y otros. Comparative genomic analysis revealed speci- fic mutation pattern between human coronavirus SARS-CoV-2 and Bat-SARSr-CoV RaTG13. Cell Discovery 6:11, 2020.
Tripet B, Howard MW, Jobling M, Holmes RK, Holmes KV, Hodges RS. Structural characterization of the SARS- coronavirus spike S fusion protein core. J Biol Chem 279:20836, 2004.
Weissenhorn W y otros. Crystal structure of the Ebola virus membrane fusion subunit, GP2, from the envelope glycoprotein ectodomain. Mol Cell 2:605–616, 1998.
Lambert DM y otros. Peptides from conserved regions of pa- ramyxovirus fusion (F) proteins are potent inhibitors of viral fusion. Proc Natl Acad Sci USA 93:2186–2191, 1996.
Normile D. Avian influenza. New H5N1 strain emerges in southern China. Science 314:742, 2006.
Wei DQ, Du QS, Sun H, Chou KC. Insights from modeling the 3D structure of H5N1 influenza virus neuraminidase and its bin- ding interactions with ligands. Biochem Biophys Res Commun 344:1048–1055, 2006.
Oldfield V, Keating GM, Plosker G. Enfuvirtide: a review of its use in the management of HIV infection. Drugs 65:1139–1160, 2005.
Robertson D. US FDA approves new class of HIV therapeutics.Nat Biotechnol 21:470–471, 2003.
Bray BL. Large-scale manufacture of peptide therapeutics by chemical synthesis. Nat Rev Drug Discov 2:587–593, 2003.
Castagna A, Biswas P, Beretta A, Lazzarin A. The appealing story of HIV entry inhibitors: from discovery of biological me- chanisms to drug development. Drugs 65:879–904, 2005.
Keiji Kuba y otros. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury. Nature Medicine 11: 875–879, 2005.
Luhtala S y otros. Activities of angiotensin-converting enzy- mes ACE1 and ACE2 and inhibition by bioactive peptides in porcine ocular tissues. J Ocul Pharmacol Ther 25(1):23-8, 2009.

Descargas

Publicado

2020-09-21

Cómo citar

Valle Piqueras , C. (2020). Las hojas de olivo, fuente de compuestos bioactivos que podrían ayudarnos a combatir los coronavirus además de al VIH. Encuentros En La Biología, 13(174), 13–16. https://doi.org/10.24310/enbio.v13i174.17278

Número

Sección

Artículos