Of shots and oscillations

Authors

  • Liset Menéndez de la Prida

Keywords:

neuronal system, hippocampal, grid cells

Abstract

The Nobel Prize in Medicine was awarded in 2014 to John O'Keefe and Edvard and May-Britt Moser for their discoveries on the neuronal system indicating our position in space, hippocampal place cells and grid cells of entorhinal cortex. What are these cells and why is this discovery so important?

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References

O'Keefe J, Dostrovsky J. The hippocampus as a spatial map. Preliminary evidence from unit activity in the freelymoving rat. Brain Res. 1971, 34(1):171-5.

O’Keefe J, Nadel L. The hippocampus as a cognitive map. Oxford University Press 1978.

Taube, JS; Muller RU, Ranck JB Jr. "Head-direction cells recorded from the postsubiculum in freely moving rats. I. Description and quantitative analysis.". J. Neurosci. 1990, 10 (2): 420–435.

O'Keefe, J.; Burgess, N.. "Geometric determinants of the place fields of hippocampal neurons". Nature 1996, 381 (6581): 425–428.

Hafting, T.; Fyhn, M.; Molden, S.; Moser, M. -B.; Moser, E. I. "Microstructure of a spatial map in the entorhinal cortex". Nature 2005, 436 (7052): 801–806

Buzsáki G, Draguhn A. Neuronal oscillations in cortical networks. Science. 2004, 304(5679):1926-9.

Buzsáki G, Moser EI. Memory, navigation and theta rhythm in the hippocampal-entorhinal system. Nat Neurosci. 2013, 16(2):130-8.

http://hippo-circuitlab.com/2014/10/la-estructura-del- recuerdo/

Inostroza M, Brotons-Mas JR, Laurent F, Cid E, de la Prida LM. Specific impairment of "what-where-when" episodic-like memory in experimental models of temporal lobe epilepsy. J Neurosci. 2013, 33(45):17749-62.

Jefferys JG, Menendez de la Prida L, Wendling F, Bragin A, Avoli M, Timofeev I, Lopes da Silva FH. Mechanisms of physiological and epileptic HFO generation. Prog Neurobiol. 2012, 98(3):250-64.

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Published

2014-12-20

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