About sleep (and its necessity)

Authors

  • Jose Carlos Dávila

Keywords:

sleep

Abstract

Humans spend a significant part of our lives (almost a third!) sleeping. This ‘rest’ time seems to be necessary in order to be ‘awake’ for the remaining two thirds. Despite sleep being one of the most basic known behaviors, as it is present in virtually all studied animals (although in different forms), the ultimate reason for sleep remains one of the biggest mysteries of biology.

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References

Diekelmann S, Born J (2010). The memory function of sleep. Nature Rev Neurosci 11:114-126.

Kang JE, Lim MM, Bateman RJ, Lee JJ, Smyth LP, Cirrito JR, Fujiki N, Nishino S, Holtzman DM (2009). Amyloid-beta dynamics are regulated by orexin and the sleep- wake cycle. Science 326:1005-7.

Ohno K, Sakurai T (2008). Orexin neuronal circuitry: role in the regulation of sleep and wakefulness. Front Neuroendocrinol 29:70-87.

Zeitzer JM, Nishino S, Mignot E (2006). The neurobiology of hypocretins (orexins), narcolepsy and related therapeutic interventions. Trends Pharmacol Sci 27:368-74.

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Published

2011-11-20

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Artículos

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