MicroRNAs in humans: what are they and how do they intervene in our health?
DOI:
https://doi.org/10.24310/enbio.v14i178.17049Keywords:
miRNA, diseases, gene therapy, diagnosisAbstract
MicroRNAs (miRNAs) are short RNA sequences of approximately 22 nucleotides involved in gene expression regulation binding to messenger RNAs by base complementarity. They generally exert their function by silencing the expression of target genes by preventing the translation of messengers or promoting their degradation. They play a key role in our health and certain imbalances in miRNA expression levels can lead to pathologies related to abnormal gene expression, such as cancer, neurological diseases or autoimmune disorders. Therefore, miRNA profiling allows these diseases to be diagnosed and miRNA-based gene therapies may be developed in the future to treat a variety of gene-based diseases.
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